Journal: JBMR Plus

Article Title: Multi-tissue spatial transcriptomics identified simultaneous responses to oxidative stress and apoptosis in parallel with tissue-specific reprogramming in modeled chronic kidney disease-mineral and bone disorder

doi: 10.1093/jbmrpl/ziaf161

Figure Lengend Snippet: Spatial transcriptomics identified tissue subtypes in muscle and bone. (A-C) Plasma intact FGF23 and serum TNF and blood urea nitrogen (BUN) levels in control (Ctrl) and CKD-MBD (CKD) mice (* p < .05; ** p < .01; *** p < .001 vs controls). H&E bone-muscle cross-sections for Ctrl (D) and CKD (E) and the Seurat clusters mapped on the sections (F and G). (H) Tissue and fiber type specific marker gene expression. (I) UMAP of Ctrl and CKD samples, with major tissue and muscle fiber types labeled. (J) Localization of major muscle fiber types in Ctrl and CKD tissue sections (colors correspond to UMAP in H).

Article Snippet: Plasma FGF23 was assessed using a rodent specific commercial ELISA for bioactive, intact FGF23 (“iFGF23”; Quidel, Inc.).

Techniques: Clinical Proteomics, Control, Marker, Gene Expression, Labeling

Journal: Nephrology (Carlton, Vic.)

Article Title: Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c‐terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients

doi: 10.1111/nep.12909

Figure Lengend Snippet: Subjects’ serum intact FGF23 and C‐terminal FGF23 levels and intact FGF23:C‐terminal FGF23 ratios at the baseline and after 3 months’ sodium ferrous citrate treatment. The iFGF23 (pg/mL) and cFGF23 (pmol/L) measurements were obtained simultaneously, and the unit conversion of the cFGF23 data was performed using the following equation: 0.133 pmol/L = 1 pg/mL. The data are expressed as median values and interquartile ranges. * P < 0.05 compared with the baseline values.

Article Snippet: The clinical biochemical analyses were performed at our hospital's laboratory, but the patients’ serum ferritin, intact PTH (iPTH), intact FGF23 (iFGF23), and C‐terminal FGF23 (cFGF23) levels were measured by SRL Inc. (Tokyo, Japan).

Techniques:

Journal: Nephrology (Carlton, Vic.)

Article Title: Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c‐terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients

doi: 10.1111/nep.12909

Figure Lengend Snippet: Variables contributing to the differences between the log serum intact FGF23 levels seen at the baseline and after 3 months’ sodium ferrous citrate supplementation

Article Snippet: The clinical biochemical analyses were performed at our hospital's laboratory, but the patients’ serum ferritin, intact PTH (iPTH), intact FGF23 (iFGF23), and C‐terminal FGF23 (cFGF23) levels were measured by SRL Inc. (Tokyo, Japan).

Techniques:

Journal: Nephrology (Carlton, Vic.)

Article Title: Oral iron supplementation with sodium ferrous citrate reduces the serum intact and c‐terminal fibroblast growth factor 23 levels of maintenance haemodialysis patients

doi: 10.1111/nep.12909

Figure Lengend Snippet: Variables contributing to the differences between the log serum c‐terminal FGF23 levels seen at the baseline and after 3 months’ sodium ferrous citrate supplementation

Article Snippet: The clinical biochemical analyses were performed at our hospital's laboratory, but the patients’ serum ferritin, intact PTH (iPTH), intact FGF23 (iFGF23), and C‐terminal FGF23 (cFGF23) levels were measured by SRL Inc. (Tokyo, Japan).

Techniques: